RBC Cuts Price Target on Alnylam Pharmaceuticals to $465 From $500, Keeps Outperform Rating
AI Sentiment
Highly Positive
8/10
as of 01-23-2026 3:53pm EST
Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia. It also has several clinical programs across various therapeutic areas: genetic medicines; cardio-metabolic diseases; hepatic infectious diseases, and CNS/ocular diseases. Upfront fees from research partnerships have boosted Alnylam's cash levels, and the company stands to see additional milestones and royalties from drugs commercialized under collaboration partnerships.
| Founded: | 2002 | Country: | United States |
| Employees: | N/A | City: | CAMBRIDGE |
| Market Cap: | 52.9B | IPO Year: | 2004 |
| Target Price: | $482.77 | AVG Volume (30 days): | 1.3M |
| Analyst Decision: | Strong Buy | Number of Analysts: | 27 |
| Dividend Yield: | N/A | Dividend Payout Frequency: | N/A |
| EPS: | 0.33 | EPS Growth: | N/A |
| 52 Week Low/High: | $205.87 - $495.55 | Next Earning Date: | 02-12-2026 |
| Revenue: | $3,210,070,000 | Revenue Growth: | 53.24% |
| Revenue Growth (this year): | 70.4% | Revenue Growth (next year): | 43.15% |
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Disclaimer: This prediction is generated by an AI model and should not be considered as financial advice. Always conduct your own research and consult with financial professionals before making investment decisions.
CSO & EVP, Head of Research
Avg Cost/Share
$370.80
Shares
2,290
Total Value
$848,064.62
Owned After
21,386
CSO & EVP, Head of Research
Avg Cost/Share
$364.80
Shares
1,510
Total Value
$547,927.38
Owned After
21,386
Chief Executive Officer
Avg Cost/Share
$364.80
Shares
9,577
Total Value
$3,475,156.51
Owned After
87,209
EVP Chief R&D
Avg Cost/Share
$364.80
Shares
1,510
Total Value
$547,928.97
Owned After
22,559
EVP, Chief Commercial Officer
Avg Cost/Share
$364.80
Shares
1,510
Total Value
$547,927.38
Owned After
29,778
EVP, Chief Financial Officer
Avg Cost/Share
$364.80
Shares
2,780
Total Value
$1,008,765.87
Owned After
60,173
CSO & EVP, Head of Research
Avg Cost/Share
$456.70
Shares
12,128
Total Value
$5,483,989.61
Owned After
21,386
Chief Executive Officer
Avg Cost/Share
$451.86
Shares
10,000
Total Value
$4,512,681.86
Owned After
87,209
Chief Executive Officer
Avg Cost/Share
$453.42
Shares
15,650
Total Value
$7,100,321.56
Owned After
87,209
| Insider | Ticker | Relationship | Date | Transaction | Avg Cost | Shares | Total Value | Owned After | SEC Forms |
|---|---|---|---|---|---|---|---|---|---|
| Fitzgerald Kevin Joseph | ALNY | CSO & EVP, Head of Research | Jan 13, 2026 | Sell | $370.80 | 2,290 | $848,064.62 | 21,386 | |
| Fitzgerald Kevin Joseph | ALNY | CSO & EVP, Head of Research | Jan 12, 2026 | Sell | $364.80 | 1,510 | $547,927.38 | 21,386 | |
| Greenstreet Yvonne | ALNY | Chief Executive Officer | Jan 12, 2026 | Sell | $364.80 | 9,577 | $3,475,156.51 | 87,209 | |
| Garg Pushkal | ALNY | EVP Chief R&D | Jan 12, 2026 | Sell | $364.80 | 1,510 | $547,928.97 | 22,559 | |
| Tanguler Tolga | ALNY | EVP, Chief Commercial Officer | Jan 12, 2026 | Sell | $364.80 | 1,510 | $547,927.38 | 29,778 | |
| Poulton Jeffrey V. | ALNY | EVP, Chief Financial Officer | Jan 12, 2026 | Sell | $364.80 | 2,780 | $1,008,765.87 | 60,173 | |
| Fitzgerald Kevin Joseph | ALNY | CSO & EVP, Head of Research | Nov 17, 2025 | Sell | $456.70 | 12,128 | $5,483,989.61 | 21,386 | |
| Greenstreet Yvonne | ALNY | Chief Executive Officer | Nov 13, 2025 | Sell | $451.86 | 10,000 | $4,512,681.86 | 87,209 | |
| Greenstreet Yvonne | ALNY | Chief Executive Officer | Nov 12, 2025 | Sell | $453.42 | 15,650 | $7,100,321.56 | 87,209 |
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AI Sentiment
Highly Positive
8/10
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