PTCT

EX-99.1

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EX-99.1

Exhibit 99.1

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PTC Therapeutics Provides Corporate Update and Reports Second Quarter 2026 Financial Results ​

– Robust Q2 performance with total revenue of $361 million, including $239 million of product revenue –

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– Full-year 2026 expected total revenue increased to $1.18 to $1.28 billion, with full-year product revenue guidance raised to $850 to $950 million –

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– Sephience™ (sepiapterin) Q2 2026 revenue of $151 million, with continued broad uptake and geographical expansion –

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– Strong cash position of $2.2 billion as of June 30, 2026 –

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WARREN, N.J., July 30, 2026 – PTC Therapeutics, Inc., (NASDAQ: PTCT) today announced a corporate update and financial results for the second quarter ended June 30, 2026.

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“Our teams delivered another strong quarter enabling us to again raise 2026 product revenue guidance," said Matthew B. Klein, M.D., Chief Executive Officer. “We also made a number of advances in our R&D pipeline, including identification of our next small molecule splicing development candidate, PTC303, targeting somatic expansion disorders including Huntington’s disease and myotonic dystrophy. In addition, we initiated the Phase 1 study of PTC612, our differentiated NLRP3 small molecule.”

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Key Corporate Updates

●Q2 2026 total revenue of $361 million, including $239 million of product revenue

●Sephience global launch continues with strong momentum

oQ2 2026 revenue of $151 million, with the majority from the US and increasing contributions internationally

o1,647 patients on commercial therapy worldwide as of June 30, 2026

●Positive results from votoplam PIVOT-HD long-term extension study reported and enrollment in global Phase 3 INVEST-HD study ongoing

oPIVOT-HD 24-month results demonstrated dose-dependent disease slowing on cUHDRS scale in Stage 2 participants, reaching 52% at 10 mg dose level

oPlan to engage with FDA in 2H 2026 to discuss PIVOT-HD 24-month results being finalized

oINVEST-HD study being conducted and funded by partner Novartis with target enrollment of approximately 770 individuals with early symptomatic disease

oINVEST-HD initiation triggered a $50 million milestone payment from Novartis to PTC in Q2 2026

●Vatiquinone PROVE-FA study to support NDA resubmission for treatment of Friedreich’s ataxia expected to initiate in Q3 2026

oGlobal study will enroll approximately 120 individuals with Friedreich’s ataxia age 7 to 21

oStudy includes open-label treatment arm with matched natural history control group

●PTC pipeline continues to advance

oPTC303 named as MSH3 splicing program development candidate targeting Huntington’s disease and myotonic dystrophy with plan to enter clinic in 2027

oPhase 1 study of PTC612, an oral NLRP3 inhibitor, initiated in Q2 2026

oPhase 2a study of PTC844, a next-generation DHODH inhibitor, expected to initiate in Q3 2026

●Hege Sollie-Zetlmayer has been appointed to PTC’s Board of Directors. Ms. Sollie-Zetlmayer has over 30 years of experience in the biopharmaceutical and medical device industry as a global business operations and human resources leader. She most recently served as PTC’s Chief Human Resources Officer prior to her retirement in June 2026.

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Second Quarter 2026 Financial Highlights

●Total net product revenue and royalty revenue was $309.9 million for the second quarter of 2026, compared to $175.9 million for the second quarter of 2025.

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●Total net product revenue across the commercial portfolio was $238.8 million for the second quarter of 2026, compared to $118.3 million for the second quarter of 2025, representing over 100% increase.

●Sephience net product revenues were $151.3 million for the second quarter of 2026, representing 21% growth compared to the first quarter of 2026.

●Translarna™ (ataluren) net product revenues were $42.2 million for the second quarter of 2026, compared to $59.5 million for the second quarter of 2025.

●Emflaza® (deflazacort) net product revenues were $24.6 million for the second quarter of 2026, compared to $36.4 million for the second quarter of 2025, due to continued generic erosion.

●Roche reported Evrysdi® (risdiplam) year-to-date sales of approximately 968 CHF million, resulting in royalty revenue of $71.1 million to PTC for the second quarter of 2026, compared to $57.6 million to PTC for the second quarter of 2025.

●In the second quarter of 2026, PTC recorded a development milestone of $50.0 million from Novartis for the first patient dosed in the ongoing INVEST-HD Phase 3 study. This sales milestone was recorded as collaboration revenue.

●Based on US GAAP (Generally Accepted Accounting Principles), GAAP R&D expenses were $99.2 million for the second quarter of 2026, compared to $113.0 million for the second quarter of 2025.

●Non-GAAP R&D expenses were $88.6 million for the second quarter of 2026, excluding $10.5 million in non-cash, stock-based compensation expense, compared to $104.0 million for the second quarter of

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PTC THERAPEUTICS, INC._February 19, 2026 0001070081false00010700812026-02-192026-02-19 ​ ​

UNITED STATES

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SECURITIES AND EXCHANGE COMMISSION

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WASHINGTON, D.C. 20549

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FORM 8-K

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CURRENT REPORT

​ Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 ​ Date of Report (Date of earliest event reported): February 19, 2026 ​

PTC THERAPEUTICS, INC.

​ (Exact Name of Company as Specified in Charter) ​ ​

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Delaware ​ ​ ​ 001-35969 ​ ​ ​ 04-3416587

(State or Other Jurisdiction ​ (Commission ​ (IRS Employer

of Incorporation) ​ File Number) ​ Identification No.)

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500 Warren Corporate Center Drive ​ ​ ​ ​ ​

Warren, NJ ​ ​ 07059

(Address of Principal Executive Offices) ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code: (908) 222-7000 ​ Not applicable (Former Name or Former Address, if Changed Since Last Report) ​ Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ​ ☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ​ ☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ​ ☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ​ ☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​ ​

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Title of each class ​ ​ ​ Trading Symbol(s) ​ ​ ​ Name of each exchange on which registered

Common Stock, $0.001 par value per share ​

PTCT

​ Nasdaq Global Select Market

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter). ​ Emerging growth company ☐ ​ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐ ​ ​ ​ ​

Item 2.02. Results of Operations and Financial Condition. On February 19, 2026, PTC Therapeutics, Inc. (the “Company”) announced its financial results for the quarter and fiscal year ended December 31, 2025. The full text of the press release issued in connection with the announcement is furnished as Exhibit 99.1 to this Current Report on Form 8-K (this "Report") and is incorporated by reference into this Item 2.02. Item 7.01. Regulation FD Disclosure. The Company will host a conference call on February 19, 2026 at 4:30 p.m. eastern time, as previously announced. During this call the Company expects to review financial results for the quarter and fiscal year ended December 31, 2025, as well as other corporate highlights and updates. Instructions on how to access the conference call are included in the press release furnished as Exhibit 99.1 hereto. The information in this Report (including Items 2.02 and 7.01 and Exhibit 99.1) shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing. All website addresses given in this Report or incorporated herein by reference are for information only and are not intended to be an active link or to incorporate any website information into this Report. Item 9.01. Financial Statements and Exhibits. (d) Exhibits ​

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Exhibit No. ​ ​ ​ Description

99.1 ​ Press Release, dated February 19, 2026 issued by PTC Therapeutics, Inc.

104 ​ The cover page from this Current Report on Form 8-K, formatted in Inline XBRL

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​ Signature Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this Report to be signed on its behalf by the undersigned hereunto duly authorized. ​

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​ PTC Therapeutics, Inc.

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Date: February 19, 2026 By: /s/ Pierre Gravier

​ Name: Pierre Gravier

​ Title: Chief Financial Officer

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