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AI Earnings Predictions for Protalix BioTherapeutics Inc. (DE) (PLX)

Machine learning predictions based on historical earnings data and price patterns

Latest Prediction

SELL

1-Day Prediction

-1.91%

$1.90

0% positive prob.

5-Day Prediction

-8.50%

$1.77

0% positive prob.

20-Day Prediction

-11.81%

$1.71

0% positive prob.

Price at prediction: $1.94 Confidence: 100.0% Model AUC: 1.0000 Quarter: Q3 2025

Earnings Transcripts

SEC 8-K filings with transcript text

View All
2025
Q3

Q3 2025 Earnings

8-K SELL

Nov 13, 2025 · 100% conf.

AI Prediction SELL

1D

-1.91%

$1.90

Act: -4.38%

5D

-8.50%

$1.77

Act: -10.31%

20D

-11.81%

$1.71

Act: -7.73%

Price: $1.94 Prob +5D: 0% AUC: 1.000
0001104659-25-110821

Protalix BioTherapeutics, Inc._November 13, 2025 0001006281false00010062812025-11-132025-11-13 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 13, 2025

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On November 13, 2025, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended September 30, 2025 and provided a business and clinical update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated November 13, 2025

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: November 13, 2025

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2025
Q2

Q2 2025 Earnings

8-K

Aug 14, 2025

0001558370-25-011468

0001006281false00010062812025-08-142025-08-14 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 14, 2025

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On August 14, 2025, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended June 30, 2025 and provided a business and clinical update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated August 14, 2025

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: August 14, 2025

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2025
Q1

Q1 2025 Earnings

8-K

May 9, 2025

0001558370-25-007060

0001006281false00010062812025-05-092025-05-09 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 9, 2025

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On May 9, 2025, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended March 31, 2025 and provided a business and clinical update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated May 9, 2025

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: May 9, 2025

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2024
Q4

Q4 2024 Earnings

8-K

Mar 17, 2025

0001558370-25-003036

0001006281false00010062812025-03-172025-03-17 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 17, 2025

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On March 17, 2025, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal year ended December 31, 2024 and provided a business and clinical update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated March 17, 2025

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: March 17, 2025

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2024
Q3

Q3 2024 Earnings

8-K

Nov 14, 2024

0001558370-24-015608

0001006281false00010062812024-11-142024-11-14 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 14, 2024

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On November 14, 2024, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended September 30, 2024 and provided a business and clinical update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ​ Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated November 14, 2024

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: November 14, 2024

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2024
Q2

Q2 2024 Earnings

8-K

Aug 14, 2024

0001558370-24-012133

0001006281false00010062812024-08-142024-08-14 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 14, 2024

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On August 14, 2024, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended June 30, 2024 and provided a business update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ​ Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated August 14, 2024

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: August 14, 2024

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2024
Q1

Q1 2024 Earnings

8-K

May 10, 2024

0001558370-24-007692

0001006281false00010062812024-05-102024-05-10 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 10, 2024

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On May 10, 2024, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal year ended March 31, 2024 and provided a business update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ​ Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated May 10, 2024

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: May 10, 2024

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2023
Q4

Q4 2023 Earnings

8-K

Mar 14, 2024

0001558370-24-003160

0001006281false00010062812024-03-142024-03-14 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 14, 2024

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On March 14, 2024, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal year ended December 31, 2023 and provided a business update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ​ Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated March 14, 2024

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: March 14, 2024

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2023
Q3

Q3 2023 Earnings

8-K

Nov 6, 2023

0001558370-23-017657

0001006281false00010062812023-11-062023-11-06 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 6, 2023

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On November 6, 2023, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the quarter ended September 30, 2023 and provided a business update on recent regulatory, clinical and corporate developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated November 6, 2023

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: November 6, 2023

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2023
Q2

Q2 2023 Earnings

8-K

Aug 7, 2023

0001558370-23-013481

0001006281false00010062812023-08-072023-08-07 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 7, 2023

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On August 7, 2023, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the quarter ended June 30, 2023 and provided a business update on recent regulatory, clinical and corporate developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated August 7, 2023

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: August 7, 2023

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2023
Q1

Q1 2023 Earnings

8-K

May 18, 2023

0001558370-23-010154

0001006281false00010062812023-05-182023-05-18 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 18, 2023

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​

Item 2.02Results of Operations and Financial Condition On May 18, 2023, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release which, in part, disclosed the Company’s current cash and cash equivalent position. Such portions of the press release are furnished in Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the specified information in Item 2.02 of this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 8.01Other Events The press release referenced in Item 2.02 included an announcement by the Company that it is eligible to receive a $20 million milestone payment from its commercial partner, Chiesi Global Rare Diseases, a business unit of the Chiesi Group (Chiesi). The milestone payment was triggered by the approval by the U.S. Food and Drug Administration of ELFABRIO® (pegunigalsidase alfa-iwxj) for the treatment of adult patients with Fabry disease. Except as set forth in Item 2.02, a copy of the press release is attached hereto as Exhibit 99.1. Item 9.01Financial Statements and Exhibits

Exhibit No.

Description ​

99.1 ​ Press Release dated May 18, 2023

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: May 18, 2023

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2023
Q1

Q1 2023 Earnings

8-K

May 4, 2023

0001558370-23-007978

0001006281false00010062812023-05-042023-05-04 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 4, 2023

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On May 4, 2023, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the quarter ended March 31, 2023 and provided a business update on recent regulatory, clinical and corporate developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated May 4, 2023

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: May 4, 2023

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2022
Q4

Q4 2022 Earnings

8-K

Feb 27, 2023

0001558370-23-002100

0001006281false00010062812023-02-272023-02-27 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): February 27, 2023

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On February 27, 2023, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal year ended December 31, 2022 and provided a business update on recent corporate and regulatory developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated February 27, 2023

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: February 27, 2023

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2022
Q3

Q3 2022 Earnings

8-K

Nov 14, 2022

0001558370-22-017549

0001006281false00010062812022-11-092022-11-09 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 9, 2022

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On November 14, 2022, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the quarter ended September 30, 2022 and provided a business update on recent corporate and regulatory developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 8.01         Other Events

On November 14, 2022, the Company, together with its commercialization partner, Chiesi Global Rare Diseases, a business unit of the Chiesi Group, today announced the resubmission on November 9, 2022 of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for PRX-102 (pegunigalsidase alfa) for the treatment of adult patients with Fabry disease. Pegunigalsidase alfa is a purposefully-designed, long-acting recombinant, PEGylated, cross-linked α-galactosidase-A investigational product candidate. A copy of the press release is attached as Exhibit 99.2 to this Current Report on Form 8-K and is incorporated herein by reference. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated November 14, 2022 (Earnings Release)

99.2 ​ Press Release dated November 14, 2022

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: November 14, 2022

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2022
Q2

Q2 2022 Earnings

8-K

Aug 15, 2022

0001558370-22-013557

0001006281false00010062812022-08-152022-08-15 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 15, 2022

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On August 15, 2022, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the quarter ended June 30, 2022 and provided a business update on recent corporate and clinical developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated August 15, 2022

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: August 15, 2022

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2022
Q1

Q1 2022 Earnings

8-K

May 16, 2022

0001558370-22-008843

0001006281false00010062812022-05-162022-05-16 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 16, 2022

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On May 16, 2022, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the first quarter ended March 31, 2022 and provided a business update on recent clinical developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated May 16, 2022

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: May 16, 2022

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2021
Q4

Q4 2021 Earnings

8-K

Mar 31, 2022

0001558370-22-004821

0001006281false00010062812022-03-312022-03-31 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 31, 2022

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On March 31, 2022, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal year ended December 31, 2021 and provided a business update on recent corporate and clinical developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated March 31, 2022

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: March 31, 2022

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2021
Q3

Q3 2021 Earnings

8-K

Nov 15, 2021

0001558370-21-015857

0001006281false00010062812021-11-152021-11-15 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 15, 2021

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On November 15, 2021, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the third quarter ended September 30, 2021 and provided a financial and business update on recent corporate, clinical and regulatory developments. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated November 15, 2021

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: November 15, 2021

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2021
Q2

Q2 2021 Earnings

8-K

Aug 16, 2021

0001558370-21-011750

0001006281false00010062812021-08-162021-08-16 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 16, 2021

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On August 16, 2021, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the second quarter ended June 30, 2021, and provided a financial and business update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated August 16, 2021

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: August 16, 2021

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2021
Q1

Q1 2021 Earnings

8-K

May 14, 2021

0001558370-21-007154

0001006281false00010062812021-05-142021-05-14 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 14, 2021

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition

On May 14, 2021, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the first quarter ended March 31, 2021, and provided a business update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits (d)           Exhibits 99.1           Press release dated May 14, 2021 104            Cover Page Interactive Data File (embedded within the Inline XBRL document) ​ ​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: May 14, 2021

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

About Protalix BioTherapeutics Inc. (DE) (PLX) Earnings

This page provides Protalix BioTherapeutics Inc. (DE) (PLX) earnings call transcripts from SEC 8-K filings along with AI-powered predictions for post-earnings price movements. Our machine learning models analyze historical earnings data, pre-earnings price patterns, volume changes, and volatility to predict 1-day, 5-day, and 20-day returns after each earnings release.

Earnings transcripts are sourced directly from SEC EDGAR filings. Predictions are generated using gradient boosting models trained on PLX's historical earnings reactions. All predicted returns are shown as percentages, and predicted prices are calculated from the closing price at the time of prediction. Past performance does not guarantee future results.

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