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as of 03-20-2026 3:56pm EST

$24.90
$0.80
-3.11%
Stocks Health Care Medical Specialities Nasdaq

Castle Biosciences Inc is a molecular diagnostics company. The group provides test solutions for the diagnosis and treatment of dermatologic cancers, Barrett's esophagus (BE), and uveal melanoma. The product portfolio of the company includes DecisionDx-Melanoma, a risk stratification gene expression profile (GEP) test; DecisionDx-SCC, a risk stratification test for cutaneous squamous cell carcinoma; MyPath Melanoma, a diagnostic GEP test for use in patients with difficult-to-diagnose melanocytic lesions; and TissueCypher, a test to predict future development of progression of high-grade dysplasia and/or esophageal cancer. The company derives revenues through the delivery of test reports for its molecular diagnostic tests.

Founded: 2007 Country:
United States
United States
Employees: N/A City: FRIENDSWOOD
Market Cap: 806.3M IPO Year: 2019
Target Price: $47.17 AVG Volume (30 days): 398.2K
Analyst Decision: Strong Buy Number of Analysts: 6
Dividend Yield:
N/A
Dividend Payout Frequency: annual
EPS: -0.83 EPS Growth: -233.87
52 Week Low/High: $14.59 - $44.28 Next Earning Date: 05-04-2026
Revenue: $344,229,000 Revenue Growth: 3.66%
Revenue Growth (this year): 2.42% Revenue Growth (next year): 12.69%
P/E Ratio: -30.96 Index: N/A
Free Cash Flow: 28.3M FCF Growth: -22.48%

AI-Powered CSTL Daily Prediction

Machine learning model trained on 25+ technical indicators

Updated 2 days ago

AI Recommendation

hold
Model Accuracy: 73.62%
73.62%
Confidence

Disclaimer: This prediction is generated by an AI model and should not be considered as financial advice. Always conduct your own research and consult with financial professionals before making investment decisions.

Stock Insider Trading Activity of Castle Biosciences Inc. (CSTL)

MAETZOLD DEREK J

Pres. & Chief Exec. Officer

Sell
CSTL Mar 18, 2026

Avg Cost/Share

$25.39

Shares

650

Total Value

$16,503.50

Owned After

21,479

SEC Form 4

MAETZOLD DEREK J

Pres. & Chief Exec. Officer

Sell
CSTL Mar 17, 2026

Avg Cost/Share

$25.93

Shares

18,650

Total Value

$483,594.50

Owned After

21,479

SEC Form 4

MAETZOLD DEREK J

Pres. & Chief Exec. Officer

Sell
CSTL Mar 16, 2026

Avg Cost/Share

$26.32

Shares

17,575

Total Value

$456,407.52

Owned After

21,479

MAETZOLD DEREK J

Pres. & Chief Exec. Officer

Sell
CSTL Mar 13, 2026

Avg Cost/Share

$25.45

Shares

13,204

Total Value

$336,002.19

Owned After

21,479

SEC Form 4

Juvenal Tobin W

Chief Commercial Officer

Sell
CSTL Mar 12, 2026

Avg Cost/Share

$25.24

Shares

20,863

Total Value

$526,582.12

Owned After

86,825

SEC Form 4

Stokes Frank

Chief Financial Officer

Sell
CSTL Mar 5, 2026

Avg Cost/Share

$27.98

Shares

6,001

Total Value

$167,907.98

Owned After

60,085

SEC Form 4

Sell
CSTL Mar 5, 2026

Avg Cost/Share

$28.48

Shares

7,403

Total Value

$210,727.17

Owned After

19,309

Stokes Frank

Chief Financial Officer

Sell
CSTL Mar 3, 2026

Avg Cost/Share

$27.56

Shares

7,000

Total Value

$192,073.00

Owned After

60,085

MAETZOLD DEREK J

Pres. & Chief Exec. Officer

Sell
CSTL Feb 4, 2026

Avg Cost/Share

$38.22

Shares

817

Total Value

$31,035.32

Owned After

21,479

MAETZOLD DEREK J

Pres. & Chief Exec. Officer

Sell
CSTL Feb 3, 2026

Avg Cost/Share

$39.91

Shares

3,200

Total Value

$127,721.60

Owned After

21,479

SEC Form 4

Earnings Transcripts

SEC 8-K filings with transcript text

View All
2025
Q4

Q4 2025 Earnings

8-K BUY

Feb 26, 2026 · 100% conf.

AI Prediction BUY

1D

+7.09%

$34.14

Act: -7.43%

5D

+12.36%

$35.82

Act: -12.45%

20D

+11.73%

$35.62

Price: $31.88 Prob +5D: 100% AUC: 1.000
0001628280-26-012263

cstl-202602260001447362FALSE00014473622026-02-262026-02-26

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): February 26, 2026

Castle Biosciences, Inc. (Exact name of registrant as specified in its charter)

Delaware 001-38984 77-0701774 (state or other jurisdiction of incorporation) (Commission File Number) (I.R.S. Employer Identification No.)

1500 W. Parkwood Ave, Suite 400 Friendswood, Texas 77546 (Address of principal executive offices)(Zip Code)

Registrant’s telephone number, including area code: (866) 788-9007

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐    Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act: Title of each classTrading Symbol(s) Name of each exchange on which registered Common Stock, $0.001 par value per shareCSTL The Nasdaq Global Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b–2 of the Securities Exchange Act of 1934 (§ 240.12b–2 of this chapter). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02    Results of Operations and Financial Condition.

On February 26, 2026, Castle Biosciences, Inc. (the “Company”) issued a press release announcing its financial results for the fourth quarter and year ended December 31, 2025. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated herein by reference.

The information contained or incorporated in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any filing under the Exchange Act or the Securities Act of 1933, as amended (the “Securities Act”), except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.

Item 7.01    Regulation FD Disclosure.

On February 26, 2026, the Company made available the slide presentation attached hereto as Exhibit 99.2. Information from these slide presentations may also be used by the management of the Company in future meetings regarding the Company.

The information contained or incorporated in this Item 7.01 of this Current Report on Form 8-K, including Exhibit 99.2, shall not be deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any filing under the Exchange Act or the Securities Act except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.

Item 9.01    Financial Statements and Exhibits. (d) Exhibits.

Exhibit NumberDescription 99.1Press release issued February 26, 2026.

99.2Slide presentation.

104Inline XBRL for the cover page of this Current Report on Form 8-K.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

CASTLE BIOSCIENCES, INC.

By:/s/ Frank Stokes Frank Stokes Chief Financial Officer Date: February 26, 2026

2025
Q4

Q4 2025 Earnings

8-K BUY

Jan 13, 2026 · 100% conf.

AI Prediction BUY

1D

+7.09%

$34.14

Act: -7.43%

5D

+12.36%

$35.82

Act: -12.45%

20D

+11.73%

$35.62

Price: $31.88 Prob +5D: 100% AUC: 1.000
0001628280-26-001909

cstl-202601110001447362FALSE00014473622026-01-112026-01-11

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): January 11, 2026

Castle Biosciences, Inc. (Exact name of registrant as specified in its charter)

Delaware 001-38984 77-0701774 (state or other jurisdiction of incorporation) (Commission File Number) (I.R.S. Employer Identification No.)

505 S. Friendswood Drive, Suite 401 Friendswood, Texas 77546 (Address of principal executive offices)(Zip Code)

Registrant’s telephone number, including area code: (866) 788-9007

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐    Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act: Title of each classTrading Symbol(s)Name of each exchange on which registered Common Stock, $0.001 par value per shareCSTLThe Nasdaq Global Market

Indicate by check mark whether the registrant is an emerging growth company as defined in as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b–2 of the Securities Exchange Act of 1934 (§ 240.12b–2 of this chapter). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02    Results of Operations and Financial Condition.

On January 11, 2026, Castle Biosciences, Inc. (the “Company”) issued a press release announcing certain preliminary performance results for the fourth quarter of 2025 and for the year ended December 31, 2025. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated herein by reference.

The information contained or incorporated in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any filing under the Exchange Act or the Securities Act of 1933, as amended (the “Securities Act”), except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.

Item 7.01    Regulation FD Disclosure.

On January 11, 2026, the Company made available the slide presentation attached hereto as Exhibit 99.2. Information from this slide presentation may also be used by the management of the Company in future meetings regarding the Company.

The information contained or incorporated in this Item 7.01 of this Current Report on Form 8-K, including Exhibit 99.2, shall not be deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any filing under the Exchange Act or the Securities Act except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.

Item 9.01    Financial Statements and Exhibits. (d) Exhibits. Exhibit NumberDescription 99.1Press release issued January 11, 2026.

99.2Slide presentation.

104Inline XBRL for the cover page of this Current Report on Form 8-K.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

CASTLE BIOSCIENCES, INC.

By:/s/ Frank Stokes Frank Stokes Chief Financial Officer Date: January 11, 2026

2025
Q3

Q3 2025 Earnings

8-K

Nov 3, 2025

0001628280-25-048248

cstl-202511030001447362FALSE00014473622025-11-032025-11-03

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): November 3, 2025

Castle Biosciences, Inc. (Exact name of registrant as specified in its charter)

Delaware 001-38984 77-0701774 (state or other jurisdiction of incorporation) (Commission File Number) (I.R.S. Employer Identification No.)

505 S. Friendswood Drive, Suite 401 Friendswood, Texas 77546 (Address of principal executive offices)(Zip Code)

Registrant’s telephone number, including area code: (866) 788-9007

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐    Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act: Title of each classTrading Symbol(s) Name of each exchange on which registered Common Stock, $0.001 par value per shareCSTL The Nasdaq Global Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b–2 of the Securities Exchange Act of 1934 (§ 240.12b–2 of this chapter). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02    Results of Operations and Financial Condition.

On November 3, 2025, Castle Biosciences, Inc. (the “Company”) issued a press release announcing its financial results for the third quarter ended September 30, 2025. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated herein by reference.

The information contained or incorporated in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any filing under the Exchange Act or the Securities Act of 1933, as amended (the “Securities Act”), except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.

Item 7.01    Regulation FD Disclosure.

On November 3, 2025, the Company made available the slide presentation attached hereto as Exhibit 99.2. Information from this slide presentation may also be used by the management of the Company in future meetings regarding the Company.

The information contained or incorporated in this Item 7.01 of this Current Report on Form 8-K, including Exhibit 99.2, shall not be deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any filing under the Exchange Act or the Securities Act except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.

Item 9.01    Financial Statements and Exhibits. (d) Exhibits. Exhibit NumberDescription 99.1Press release issued November 3, 2025.

99.2Slide presentation.

104Inline XBRL for the cover page of this Current Report on Form 8-K.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

CASTLE BIOSCIENCES, INC.

By:/s/ Frank Stokes Frank Stokes Chief Financial Officer Date: November 3, 2025

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