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Biogen and Idec merged in 2003, combining forces to market Biogen's multiple sclerosis drug Avonex and Idec's cancer drug Rituxan. Today, Rituxan and next-generation antibody Gazyva (oncology) and Ocrevus (multiple sclerosis) are marketed via a collaboration with Roche. Biogen markets several multiple sclerosis drugs including Plegridy, Tysabri, Tecfidera, and Vumerity. Biogen's newer products include Spinraza (SMA, with partner Ionis), Leqembi (Alzheimers, with partner Eisai), Skyclarys (Friedreich's Ataxia, Reata), Zurzuvae (postpartum depression, Sage), and Qalsody (ALS, Ionis). Biogen has several drug candidates in phase 3 trials in neurology, immunology, and rare diseases.
Carnival is the largest global cruise company, with 92 ships in service at the end of fiscal 2023. Its portfolio of brands includes Carnival Cruise Line, Holland America Line, Princess, and Seabourn in North America; P&O Cruises and Cunard in the United Kingdom; Aida in Germany; and Costa Cruises in Southern Europe. It's currently folding its P&O Australia brand into Carnival. The firm also operates Holland America and Princess Alaska tours in Alaska and the Canadian Yukon. Carnival's brands attracted nearly 13 million guests in 2019 before covid-19, a level it reached again in 2023.