AFG vs IONS Comparison

American Financial Group Inc is a holding company that is engaged in property and casualty insurance services. The company has a focus on specialized commercial products for businesses. The Company operates through two segments: Property & Casualty Insurance and Other. The Property & Casualty segment includes Property & Transportation, covering buses, trucks, marine, agriculture, and commercial property; Specialty Casualty, offering excess & surplus, liability, and professional insurance; and Specialty Financial, providing risk management for lending and leasing institutions, fidelity and surety products, and trade credit insurance. The company's insurance operations are conducted through the Great American Insurance Group.

Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.