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Protalix BioTherapeutics Inc is a biopharmaceutical company focused on the development and commercialization of recombinant therapeutic proteins based on its proprietary ProCellEx protein expression system or ProCellEx. It has developed taliglucerase alfa for the treatment of Gaucher disease. The company's products also treat diseases like Fabry disease and cystic fibrosis. The company's primary sources of revenue include its sales of BioManguinhos alfataliglicerase in Brazil and of drug substances to Pfizer under its Amended Pfizer Agreement. The company's pipeline consists of ELFABRIO, Uricase, and Long Acting DNase I.

Founded: 1993 Country:
United States
United States
Employees: N/A City: HACKENSACK
Market Cap: 230.0M IPO Year: 1996
Target Price: $12.00 AVG Volume (30 days): 1.4M
Analyst Decision: Strong Buy Number of Analysts: 1
Dividend Yield:
N/A
Dividend Payout Frequency: N/A
EPS: -0.01 EPS Growth: -55.56
52 Week Low/High: $1.34 - $3.19 Next Earning Date: N/A
Revenue: $53,399,000 Revenue Growth: -18.47%
Revenue Growth (this year): 9.67% Revenue Growth (next year): 23.86%
P/E Ratio: -262.00 Index: N/A
Free Cash Flow: 7.4M FCF Growth: N/A

Stock Insider Trading Activity of Protalix BioTherapeutics Inc. (DE) (PLX)

Bashan Dror

PRESIDENT AND CEO

Buy
PLX Dec 19, 2025

Avg Cost/Share

$1.81

Shares

56,000

Total Value

$101,360.00

Owned After

188,516

SEC Form 4

Earnings Transcripts

SEC 8-K filings with transcript text

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2025
Q3

Q3 2025 Earnings

8-K SELL

Nov 13, 2025 · 100% conf.

AI Prediction SELL

1D

-1.91%

$1.90

5D

-8.50%

$1.77

20D

-11.81%

$1.71

Price: $1.94 Prob +5D: 0% AUC: 1.000
0001104659-25-110821

Protalix BioTherapeutics, Inc._November 13, 2025 0001006281false00010062812025-11-132025-11-13 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 13, 2025

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On November 13, 2025, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended September 30, 2025 and provided a business and clinical update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated November 13, 2025

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: November 13, 2025

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2025
Q2

Q2 2025 Earnings

8-K

Aug 14, 2025

0001558370-25-011468

0001006281false00010062812025-08-142025-08-14 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 14, 2025

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On August 14, 2025, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended June 30, 2025 and provided a business and clinical update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated August 14, 2025

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: August 14, 2025

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

2025
Q1

Q1 2025 Earnings

8-K

May 9, 2025

0001558370-25-007060

0001006281false00010062812025-05-092025-05-09 ​ ​

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 9, 2025

Protalix BioTherapeutics, Inc. (Exact name of registrant as specified in its charter)

​ ​

Delaware

001-33357

65-0643773

(State or other jurisdiction of incorporation) ​ (Commission File Number) ​ (IRS Employer Identification No.)

​ ​ ​ ​ ​

2 University Plaza ​ ​ ​ ​

Suite 100 ​ ​ ​ ​

Hackensack, NJ ​ ​ ​ 07601

(Address of principal executive offices) ​ ​ ​ (Zip Code)

​ Registrant’s telephone number, including area code 201-696-9345 (Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): ☐    Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ​ Securities registered pursuant to Section 12(b) of the Act: ​

Title of each class Trading Symbol(s) Name of each exchange on which registered

Common stock, $0.001 par value PLX NYSE American

​ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻ ​ ​ ​ ​

Item 2.02         Results of Operations and Financial Condition On May 9, 2025, Protalix BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the fiscal quarter ended March 31, 2025 and provided a business and clinical update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K. In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01         Financial Statements and Exhibits

Exhibit No.

Description

99.1 ​ Press Release dated May 9, 2025

104 ​ Cover Page Interactive Data File (embedded within the Inline XBRL document)

​ ​ ​

​ ​ ​

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: May 9, 2025

PROTALIX BIOTHERAPEUTICS, INC.

​ ​

By: /s/ Dror Bashan

Name: Dror Bashan

Title: President and Chief Executive Officer

​ ​

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